F Formulation Study of Acetosal Suppositories Using PEG 400 and PEG 6000: Impact on Physical Properties

Abstract

Asetosal suppositories are solid preparations in the shape of a torpedo that contain the active ingredient asetosal and are used rectally. The base of the suppository plays an important role in the rate of drug release, both systemically and locally. The aim of this study is to determine the effect of varying concentrations of PEG 400 and PEG 6000 bases on the physical properties of acetosal suppositories. Three formulations with base concentration ratios (PEG 400 : PEG 6000) F1 = 3:7, F2 = 1:1, F3 = 7:3. The testing of the physical properties of acetosal suppositories includes organoleptic, weight uniformity, melting time, melting point, and hardness, and the results are then compared with the literature. The research results show that variations in the concentration of PEG 400 and PEG 6000 in acetosal suppositories affect the physical properties, namely weight uniformity, melting time, melting point, and hardness. Variations in the concentration of PEG 400 and PEG 6000 do not affect the organoleptic physical properties of shape, smell, and color.